| Protocol ID | NCT00477087 |
| Registration Date | 2007-05-22 |
| Status | Terminated |
| Sponsor | Stanford University |
| Country | United States |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2006-07-01 |
| Last Patient Out | 2010-01-01 |
| Publication | y |
| Gender % | MALE |
| Mean Age | 18 Years - 75 Years |
NCT00477087
Phase II Study of Granulocyte-Macrophage Colony Stimulating Factor Plus Mitoxantrone for the Treatment of Hormone Refractory Prostate Cancer
| Field |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 4868ms / 10208 tok |
OPENAI
gpt-4o Thinking: o3 4617ms / 8772 tok |
GLM
glm-5.1 6544ms / 8925 tok |
Review |
|---|---|---|---|---|
| rct_type | N/A | N/A | N/A | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place | other | other | hospital | – |
| feasibility | feasibility RCT | feasibility RCT | feasibility RCT | OK |
| intervention_pharmacologic | yes | yes | yes | OK |
| intervention_chemo_immuno_radio | yes | yes | yes | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex |
no
no → no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — This is a pharmacologic intervention combining two drugs (mitoxantrone chemotherapy and GM-CSF) that work through different mechanisms but both fall within the same category of drug treatment.
Thinking: no — This is a combination of two pharmacologic agents (GM-CSF and mitoxantrone) without complex interactions between components
|
no
yes → yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: yes — The intervention combines two different types: pharmacologic (Mitoxantrone) and biologic response modifier (GM-CSF) which are distinct categories and have different mechanisms of action.
Thinking: no — The intervention combines two drugs, both pharmacologic agents, so it is a single‐category treatment rather than a multi-component intervention from different categories.
|
no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | no | no | no | OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | chemotherapy | chemotherapy | chemotherapy | OK |