NCT01949974

✓ Unanimous Initial: outpatient Requery: mixed — The intervention explicitly includes outpatient monitoring, 24h phone assistance, home visits, and support should hospitalization be required, indicating both inpatient and outpatient care.

✓ Unanimous Initial: mixed Requery: outpatient — The Integral Attention Program explicitly mentions outpatient monitoring, home visits, and 24h phone assistance, indicating the intervention is primarily delivered in outpatient settings where patients go home between visits. Thinking: outpatient — The interventions involve outpatient monitoring, home visits, and phone assistance, with patients traveling from home for chemotherapy and clinic visits rather than being admitted.

✓ Unanimous Initial: outpatient Requery: outpatient — The trial mentions outpatient monitoring, home visits, and emphasizes care without requiring admission, indicating an outpatient setting. Thinking: outpatient — Interventions (palliative chemotherapy and the Integral Attention Program) are provided via outpatient visits, home monitoring, and phone support without requiring hospital admission.

✓ Unanimous Initial: no Requery: no — The experimental intervention being tested is the non-pharmaceutical Integral Attention Program (PAI), while the chemotherapy is considered the standard of care comparator.

✓ Unanimous Initial: yes Requery: yes — The experimental intervention includes standard palliative chemotherapy, which is a pharmacologic drug intervention. Thinking: no — The experimental intervention being tested is the Integral Attention Program (PAI), which is explicitly described as a non-pharmaceutical intervention involving care planning, psychological support, and other supportive services.

✓ Unanimous Initial: yes Requery: no — The experimental intervention is the Integral Attention Program, which is non-pharmacological. Thinking: no — The experimental intervention is the Integral Attention Program, a non-drug supportive care program, while chemotherapy is only the comparator arm.

✓ Unanimous Initial: no Requery: yes — The trial actively tests and compares the effects of palliative chemotherapy against an integral attention program in patients with advanced cancer.

✓ Unanimous Initial: yes Requery: yes — This trial directly compares standard palliative chemotherapy as one of the active interventions being tested against an integral attention program.

✓ Unanimous Initial: yes Requery: yes — The trial tests palliative chemotherapy as an active intervention in advanced cancer patients.

✓ Unanimous Initial: no Requery: no — The Integral Attention Program (PAI) is a comprehensive supportive care plan involving psychological, social, and standard palliative support, rather than a specific Complementary and Alternative Medicine (CAM) modality like acupuncture, massage, or herbal remedies.

✓ Unanimous Initial: yes Requery: yes — The Integral Attention Program includes art therapy and mindfulness as part of the comprehensive care intervention, which are complementary medicine modalities. Thinking: no — The Integral Attention Program includes psychological support, art therapy, and mindfulness as supportive care components, but none of the specified CAM modalities (acupuncture, aromatherapy, massage, reflexology, yoga, meditation, Reiki, herbal remedies) are mentioned.

✓ Unanimous Initial: yes Requery: no — The trial's Integral Attention Program does not include CAM modalities such as acupuncture or herbal remedies, focusing instead on psychological and social support, art therapy, and mindfulness. Thinking: no — The Integral Attention Program offers psychosocial support and optional mindfulness practice, which is treated as psychological (like MBSR) rather than a complementary modality such as acupuncture or herbal remedies.

✓ Unanimous Initial: no Requery: no — The Integral Attention Program (PAI) provides comprehensive palliative care with general psychological and social support, which does not qualify as a named, structured psychological therapy.

✓ Unanimous Initial: yes Requery: yes — The Integral Attention Program includes specialized psychological support and mindfulness, which are structured psychological interventions. Thinking: no — While PAI includes optional psychological support and voluntary mindfulness, no specific named or structured psychological therapy (CBT, ACT, MBSR, etc.) is described as a core intervention.

✓ Unanimous Initial: yes Requery: no — The Integral Attention Program includes non-specific psychological and social support, but it does not list a structured psychological therapy like CBT or MBSR. Thinking: no — The Integral Attention Program offers general palliative support and optional mindfulness/art therapy but does not specify delivery of a named, structured psychological treatment such as CBT, ACT, MBSR, etc.

✓ Unanimous Initial: no

✓ Unanimous Initial: yes Requery: no — While the Integral Attention Program includes guidance in decision-making and care planning, there is no mention of structured advance care planning conversations, advance directives, POLST, or other core ACP components as defined interventions.

✓ Unanimous Initial: no Requery: no — The Integral Attention Program focuses on pain management, decision-making, and continuity of care but does not explicitly include structured advance care planning as a core component.

✓ Unanimous Initial: N/A Requery: chemotherapy — The trial investigates standard palliative chemotherapy, which utilizes cytotoxic agents, versus a non-pharmaceutical comprehensive care program in patients with advanced cancer.

✓ Unanimous Initial: chemotherapy Requery: chemotherapy — The intervention includes standard palliative chemotherapy for advanced cancer patients, which consists of cytotoxic agents used for cancer treatment.

✓ Unanimous Initial: chemotherapy Requery: chemotherapy — The intervention includes standard palliative chemotherapy, which is a cytotoxic agent used in the treatment of cancer.