| Protocol ID | NCT02138474 |
| Registration Date | 2014-05-14 |
| Status | completed |
| Sponsor | University of Johannesburg |
| Country | South Africa |
| Industry | not industry |
| Blinding | blinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2014-04-01 |
| Last Patient Out | 2014-06-01 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - 45 Years |
NCT02138474
The Efficacy of Lacticum Acidum Homaccord in the Treatment of Chronic Tension-type Headaches
| Field |
OPENAI
gpt-4o Thinking: o3 3581ms / 8957 tok |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 9156ms / 10394 tok |
GLM
glm-5.1 8014ms / 9103 tok |
Review |
|---|---|---|---|---|
| rct_type | parallel RCT | parallel RCT | parallel RCT | OK |
| cancer_status | non-cancer | non-cancer | non-cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place | other | other | other | OK |
| feasibility | feasibility RCT | feasibility RCT | feasibility RCT | OK |
| intervention_pharmacologic | yes | yes | yes | OK |
| intervention_chemo_immuno_radio | no | no | no | OK |
| intervention_complementary | yes | yes | yes | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | yes | yes | yes | OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other |
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The primary outcome measures are related to headache symptoms and disability, fitting into the symptom category.
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — All outcomes focus on headache symptoms (modified Headache Diary) and functional impact/quality of life (Headache Disability Inventory), which fall within symptom/QoL categories.
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — All measured outcomes (headache metrics via Headache Diary and Headache Disability Inventory) focus on symptom reduction and quality of life.
|
OK |
| pharmacologic_sub |
phytotherapies
phytotherapies → phytotherapies → not yet FDA/EMA approved
shaky reasoning✗ No consensus
Initial: phytotherapies
Requery: phytotherapies — Lacticum acidum homaccord is a homeopathic remedy, which falls under plant-based/herbal medicines.
Thinking: not yet FDA/EMA approved — Homeopathic Lacticum acidum Homaccord is not an FDA- or EMA-approved drug for any indication and is being investigated experimentally for headaches.
|
other
other → phytotherapies → other
shaky reasoning✗ No consensus
Initial: other
Requery: phytotherapies — Lacticum acidum Homaccord is a homeopathic remedy derived from plant/natural sources, which falls under the category of plant-based/herbal medicines.
Thinking: other — This is a homeopathic remedy (Lacticum acidum homaccord) which is a pharmacologic intervention but does not fit into any of the specific categories listed.
|
phytotherapies
phytotherapies → other
shaky reasoning✗ No consensus
Initial: phytotherapies
Requery: other — The intervention is a homeopathic remedy (Lacticum acidum homaccord), which is a pharmacologic preparation but does not fit into the specific subcategories like controlled substances, chemotherapy, or phytotherapies.
|
|