| Protocol ID | NCT02163226 |
| Registration Date | 2014-06-13 |
| Status | completed |
| Sponsor | M.D. Anderson Cancer Center |
| Country | United States |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | multicenter RCT |
| Scope | national RCT |
| First Patient In | 2014-08-06 |
| Last Patient Out | 2020-09-02 |
| Publication | y |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT02163226
A Randomized Trial Evaluating Rapid Delivery of Dose Escalated Hypofractionated Radiotherapy for Patients Diagnosed With Bone Metastases for Effective Palliation of Symptoms
| Field |
GLM
glm-5.1 6234ms / 9742 tok |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 5470ms / 11136 tok |
OPENAI
gpt-4o Thinking: o3 3192ms / 9589 tok |
Review |
|---|---|---|---|---|
| rct_type | parallel RCT | parallel RCT | parallel RCT | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place |
other
other
shaky reasoning✓ Unanimous
Initial: other
|
other
hospital → other → other
shaky reasoning✓ Unanimous
Initial: hospital
Requery: other — This radiation therapy trial is delivered in outpatient radiation oncology departments, not requiring hospitalization or inpatient admission.
Thinking: other — The radiation therapy is delivered in an outpatient setting where patients come for 30-minute treatments and return home, not requiring hospitalization.
|
other
hospital → hospital → other
shaky reasoning✓ Unanimous
Initial: hospital
Requery: hospital — The intervention involves radiation therapy, which requires the patient to lie on a table for treatment, indicating it is delivered in a hospital setting where such facilities are available.
Thinking: other — Radiation therapy sessions are given as brief outpatient visits at a cancer center, not requiring hospitalization or home/hospice care.
|
OK |
| feasibility | fully powered RCT | fully powered RCT | fully powered RCT | OK |
| intervention_pharmacologic | no | no | no | OK |
| intervention_chemo_immuno_radio | yes | yes | yes | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative |
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The study tests radiation therapy protocols for pain palliation in bone metastases, making palliative care the setting rather than the intervention itself.
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — This trial compares two different radiation therapy dosing schedules (single dose vs. multiple doses) for bone metastases - the intervention is radiation therapy technique, not palliative care service delivery.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The trial is testing different radiation therapy regimens for pain relief in bone metastases, which is a treatment modality, not a palliative care intervention.
|
OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | yes | yes | yes | OK |
| outcome_qol | yes | yes | yes | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | N/A | N/A | N/A | OK |