NCT02163226

A Randomized Trial Evaluating Rapid Delivery of Dose Escalated Hypofractionated Radiotherapy for Patients Diagnosed With Bone Metastases for Effective Palliation of Symptoms

Extracted Fields (from Registry)
Protocol IDNCT02163226
Registration Date2014-06-13
Statuscompleted
SponsorM.D. Anderson Cancer Center
CountryUnited States
Industrynot industry
Blindingunblinded
Center Typemulticenter RCT
Scopenational RCT
First Patient In2014-08-06
Last Patient Out2020-09-02
Publicationy
Gender %ALL
Mean Age18 Years -
LLM Classifications (Side-by-Side)
Field GLM
glm-5.1
6234ms / 9742 tok
CLAUDE
claude-sonnet-4-20250514
Thinking: claude-opus-4-20250514
5470ms / 11136 tok
OPENAI
gpt-4o
Thinking: o3
3192ms / 9589 tok
Review
rct_type parallel RCT parallel RCT parallel RCT OK
cancer_status Cancer Cancer Cancer OK
non_cancer_spec N/A N/A N/A OK
setting_patient outpatient outpatient outpatient OK
setting_place other other
shaky reasoning
✓ Unanimous Initial: other
other hospital → other → other
shaky reasoning
✓ Unanimous Initial: hospital Requery: other — This radiation therapy trial is delivered in outpatient radiation oncology departments, not requiring hospitalization or inpatient admission. Thinking: other — The radiation therapy is delivered in an outpatient setting where patients come for 30-minute treatments and return home, not requiring hospitalization.
other hospital → hospital → other
shaky reasoning
✓ Unanimous Initial: hospital Requery: hospital — The intervention involves radiation therapy, which requires the patient to lie on a table for treatment, indicating it is delivered in a hospital setting where such facilities are available. Thinking: other — Radiation therapy sessions are given as brief outpatient visits at a cancer center, not requiring hospitalization or home/hospice care.
OK
feasibility fully powered RCT fully powered RCT fully powered RCT OK
intervention_pharmacologic no no no OK
intervention_chemo_immuno_radio yes yes yes OK
intervention_complementary no no no OK
intervention_device no no no OK
intervention_psychological no no no OK
intervention_complex no no no OK
intervention_acp no no no OK
intervention_music no no no OK
intervention_screening no no no OK
intervention_palliative no no → no
shaky reasoning
✓ Unanimous Initial: no Requery: no — The study tests radiation therapy protocols for pain palliation in bone metastases, making palliative care the setting rather than the intervention itself.
no yes → no
shaky reasoning
✓ Unanimous Initial: yes Requery: no — This trial compares two different radiation therapy dosing schedules (single dose vs. multiple doses) for bone metastases - the intervention is radiation therapy technique, not palliative care service delivery.
no no → no
shaky reasoning
✓ Unanimous Initial: no Requery: no — The trial is testing different radiation therapy regimens for pain relief in bone metastases, which is a treatment modality, not a palliative care intervention.
OK
intervention_education no no no OK
intervention_digital no no no OK
intervention_other no no no OK
outcome_symptom yes yes yes OK
outcome_qol yes yes yes OK
outcome_dignity no no no OK
outcome_cost no no no OK
outcome_other yes yes yes OK
pharmacologic_sub N/A N/A N/A OK
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