| Protocol ID | NCT02301143 |
| Registration Date | 2014-11-25 |
| Status | completed |
| Sponsor | Celgene |
| Country | Canada, France, Italy, Spain, United States |
| Industry | industry |
| Blinding | unblinded |
| Center Type | multicenter RCT |
| Scope | multinational RCT |
| First Patient In | 2015-04-21 |
| Last Patient Out | 2018-04-26 |
| Publication | y |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT02301143
Nab-paclitaxel (Abraxane) Plus Gemcitabine in Subjects With Locally Advanced Pancreatic Cancer (LAPC): An International, Open-label, Multi-center, Phase 2 Study (LAPACT).
| Field |
OPENAI
gpt-4o Thinking: o3 7011ms / 11278 tok |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 6239ms / 13145 tok |
GLM
glm-5.1 6360ms / 11451 tok |
Review |
|---|---|---|---|---|
| rct_type | N/A | N/A | N/A | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place | other | other | other | OK |
| feasibility |
N/A
N/A → N/A → N/A
shaky reasoning✓ Unanimous
Initial: N/A
Requery: N/A — The study is an interventional Phase 2 trial, not a randomized controlled trial (RCT).
Thinking: N/A — Single-arm Phase 2 study, not a randomized controlled trial.
|
N/A
fully powered RCT → fully powered RCT → N/A
shaky reasoning✓ Unanimous
Initial: fully powered RCT
Requery: fully powered RCT — This is a Phase 2 study with 107 participants focused on clinical efficacy outcomes (time to treatment failure, overall survival, progression-free survival) rather than feasibility metrics.
Thinking: N/A — This is a single-arm, non-randomized Phase 2 study, not an RCT.
|
N/A
N/A → N/A
shaky reasoning✓ Unanimous
Initial: N/A
Requery: N/A — This is a single-group, non-randomized Phase 2 interventional study, and therefore does not meet the criteria for a randomized controlled trial (RCT).
|
OK |
| intervention_pharmacologic | yes | yes | yes | OK |
| intervention_chemo_immuno_radio | yes | yes | yes | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | yes | yes | yes | OK |
| outcome_qol | yes | yes | yes | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | chemotherapy | chemotherapy | chemotherapy | OK |