| Protocol ID | NCT02499458 |
| Registration Date | 2015-07-16 |
| Status | completed |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
| Country | Canada |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2014-11-01 |
| Last Patient Out | 2018-12-01 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT02499458
Prospective Validation of Circulating Tumor Cells (CTCs) and Circulating Endothelial Cells (CECs) as Prognostic Biomarkers in Clear Cell Renal Cancer
| Field |
OPENAI
gpt-4o 4097ms / 8878 tok |
GLM
glm-5.1 5538ms / 9031 tok |
CLAUDE
claude-sonnet-4-20250514 4759ms / 10314 tok |
Review |
|---|---|---|---|---|
| rct_type | N/A | N/A | N/A | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place |
other
hospital → other
shaky reasoning✓ Unanimous
Initial: hospital
Requery: other — The intervention involves testing a microfluidic technology for circulating tumor cells in a cohort of patients, likely in a clinical research setting or outpatient environment rather than any specific inpatient care setting.
|
other
other → other
shaky reasoning✓ Unanimous
Initial: other
Requery: other — This is an observational biomarker study for metastatic cancer patients receiving standard targeted therapies and routine outpatient clinic blood draws, which classifies as an outpatient/community setting.
|
other
other → other
shaky reasoning✓ Unanimous
Initial: other
Requery: other — This is an observational biomarker study involving blood draws and imaging assessments that would typically occur in outpatient clinic settings rather than requiring hospitalization.
|
OK |
| feasibility | N/A | N/A | N/A | OK |
| intervention_pharmacologic | no | no | no | OK |
| intervention_chemo_immuno_radio | no | no | no | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening |
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The trial is testing CTC microfluidic technology for prognostic and predictive biomarker purposes, not for screening palliative care needs.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — This is an observational study validating prognostic biomarkers (CTCs/CECs), not testing a screening intervention to identify palliative care needs.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — This is an observational study validating biomarkers (CTCs and CECs) for prognostic purposes, not testing a screening intervention to identify palliative care needs.
|
OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | no | no | no | OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | N/A | N/A | N/A | OK |