| Protocol ID | NCT02585687 |
| Registration Date | 2015-10-23 |
| Status | Terminated |
| Sponsor | Hospices Civils de Lyon |
| Country | France |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2012-07-01 |
| Last Patient Out | 2015-10-01 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT02585687
Liver Perfusion MRI With Quantification of Tumoral Perfusion for Early Assessment of the Response of Antiangiogenics Treatments in Hepatocellular Carcinoma
| Field |
OPENAI
gpt-4o Thinking: o3 10399ms / 8627 tok |
GLM
glm-5.1 5455ms / 8776 tok |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 7884ms / 10155 tok |
Review |
|---|---|---|---|---|
| rct_type | N/A | N/A | N/A | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place |
other
hospital → hospital → other
shaky reasoning✓ Unanimous
Initial: hospital
Requery: hospital — The liver Perfusion MRI is performed on patients to assess their response to treatment, indicating the intervention requires hospital-based equipment and services, typical of an inpatient setting.
Thinking: other — The liver perfusion MRI is an outpatient imaging procedure, not requiring inpatient hospital admission.
|
other
other
shaky reasoning✓ Unanimous
Initial: other
|
other
hospital → other → other
shaky reasoning✓ Unanimous
Initial: hospital
Requery: other — The study involves MRI scanning procedures for hepatocellular carcinoma patients, which are typically performed in outpatient radiology departments or imaging centers rather than requiring hospital admission.
Thinking: other — The intervention is liver perfusion MRI performed at a medical center's radiology department as an outpatient procedure, not requiring hospital admission.
|
OK |
| feasibility |
N/A
feasibility RCT → feasibility RCT → N/A
shaky reasoning✓ Unanimous
Initial: feasibility RCT
Requery: feasibility RCT — The study has a small sample size of 28 and does not focus on clinical effectiveness but rather on early assessment of treatment response using imaging, indicating it is likely a pilot study.
Thinking: N/A — Single-group interventional study, not a randomized controlled trial.
|
N/A
N/A → N/A
shaky reasoning✓ Unanimous
Initial: N/A
Requery: N/A — The study uses a single-group, non-randomized design to assess a diagnostic device (Perfusion MRI), meaning it is not an RCT.
|
N/A
N/A → feasibility RCT → N/A
shaky reasoning✓ Unanimous
Initial: N/A
Requery: feasibility RCT — With only 28 participants and primary outcomes focused on treatment response evaluation rather than definitive clinical effectiveness, this appears to be a feasibility study assessing the utility of perfusion MRI as an early predictor of treatment response.
Thinking: N/A — Single-group interventional study without randomization or control group, not an RCT
|
OK |
| intervention_pharmacologic | no | no | no | OK |
| intervention_chemo_immuno_radio | no | no | no | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | yes | yes | yes | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening |
no
no → no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The intervention being tested is the use of liver Perfusion MRI to assess early response to treatments, not a screening tool for identifying palliative care needs.
Thinking: no — The study evaluates MRI as a diagnostic tool for treatment response, not a screening instrument for palliative-care needs.
|
no
yes → yes
shaky reasoning✓ Unanimous
Initial: yes
Requery: yes — The clinical trial's primary purpose is screening, and the intervention being tested is the use of Liver Perfusion MRI to screen for or assess the early response to antiangiogenic treatments in hepatocellular carcinoma.
|
no
yes → no → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The intervention is liver perfusion MRI being tested as an imaging technique to assess treatment response in hepatocellular carcinoma patients, not a screening tool to identify palliative care needs.
Thinking: no — The liver perfusion MRI is being used to assess treatment response to antiangiogenic therapy, not as a screening tool to identify palliative care needs.
|
OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | no | no | no | OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | N/A | N/A | N/A | OK |