NCT02585687

Liver Perfusion MRI With Quantification of Tumoral Perfusion for Early Assessment of the Response of Antiangiogenics Treatments in Hepatocellular Carcinoma

Extracted Fields (from Registry)
Protocol IDNCT02585687
Registration Date2015-10-23
StatusTerminated
SponsorHospices Civils de Lyon
CountryFrance
Industrynot industry
Blindingunblinded
Center Typesingel-center RCT
Scopenational RCT
First Patient In2012-07-01
Last Patient Out2015-10-01
Publicationn
Gender %ALL
Mean Age18 Years -
LLM Classifications (Side-by-Side)
Field OPENAI
gpt-4o
Thinking: o3
10399ms / 8627 tok
GLM
glm-5.1
5455ms / 8776 tok
CLAUDE
claude-sonnet-4-20250514
Thinking: claude-opus-4-20250514
7884ms / 10155 tok
Review
rct_type N/A N/A N/A OK
cancer_status Cancer Cancer Cancer OK
non_cancer_spec N/A N/A N/A OK
setting_patient outpatient outpatient outpatient OK
setting_place other hospital → hospital → other
shaky reasoning
✓ Unanimous Initial: hospital Requery: hospital — The liver Perfusion MRI is performed on patients to assess their response to treatment, indicating the intervention requires hospital-based equipment and services, typical of an inpatient setting. Thinking: other — The liver perfusion MRI is an outpatient imaging procedure, not requiring inpatient hospital admission.
other other
shaky reasoning
✓ Unanimous Initial: other
other hospital → other → other
shaky reasoning
✓ Unanimous Initial: hospital Requery: other — The study involves MRI scanning procedures for hepatocellular carcinoma patients, which are typically performed in outpatient radiology departments or imaging centers rather than requiring hospital admission. Thinking: other — The intervention is liver perfusion MRI performed at a medical center's radiology department as an outpatient procedure, not requiring hospital admission.
OK
feasibility N/A feasibility RCT → feasibility RCT → N/A
shaky reasoning
✓ Unanimous Initial: feasibility RCT Requery: feasibility RCT — The study has a small sample size of 28 and does not focus on clinical effectiveness but rather on early assessment of treatment response using imaging, indicating it is likely a pilot study. Thinking: N/A — Single-group interventional study, not a randomized controlled trial.
N/A N/A → N/A
shaky reasoning
✓ Unanimous Initial: N/A Requery: N/A — The study uses a single-group, non-randomized design to assess a diagnostic device (Perfusion MRI), meaning it is not an RCT.
N/A N/A → feasibility RCT → N/A
shaky reasoning
✓ Unanimous Initial: N/A Requery: feasibility RCT — With only 28 participants and primary outcomes focused on treatment response evaluation rather than definitive clinical effectiveness, this appears to be a feasibility study assessing the utility of perfusion MRI as an early predictor of treatment response. Thinking: N/A — Single-group interventional study without randomization or control group, not an RCT
OK
intervention_pharmacologic no no no OK
intervention_chemo_immuno_radio no no no OK
intervention_complementary no no no OK
intervention_device yes yes yes OK
intervention_psychological no no no OK
intervention_complex no no no OK
intervention_acp no no no OK
intervention_music no no no OK
intervention_screening no no → no → no
shaky reasoning
✓ Unanimous Initial: no Requery: no — The intervention being tested is the use of liver Perfusion MRI to assess early response to treatments, not a screening tool for identifying palliative care needs. Thinking: no — The study evaluates MRI as a diagnostic tool for treatment response, not a screening instrument for palliative-care needs.
no yes → yes
shaky reasoning
✓ Unanimous Initial: yes Requery: yes — The clinical trial's primary purpose is screening, and the intervention being tested is the use of Liver Perfusion MRI to screen for or assess the early response to antiangiogenic treatments in hepatocellular carcinoma.
no yes → no → no
shaky reasoning
✓ Unanimous Initial: yes Requery: no — The intervention is liver perfusion MRI being tested as an imaging technique to assess treatment response in hepatocellular carcinoma patients, not a screening tool to identify palliative care needs. Thinking: no — The liver perfusion MRI is being used to assess treatment response to antiangiogenic therapy, not as a screening tool to identify palliative care needs.
OK
intervention_palliative no no no OK
intervention_education no no no OK
intervention_digital no no no OK
intervention_other no no no OK
outcome_symptom no no no OK
outcome_qol no no no OK
outcome_dignity no no no OK
outcome_cost no no no OK
outcome_other yes yes yes OK
pharmacologic_sub N/A N/A N/A OK
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