NCT02790580

Dose-dense Doxorubicin/Cyclophosphamide With Intermittent Low-dose Sunitinib as Neoadjuvant or First-line Palliative Treatment of Newly Diagnosed HER2 Negative Breast Cancer Patients With Measurable Primary Breast Tumor

Extracted Fields (from Registry)
Protocol IDNCT02790580
Registration Date2016-06-06
StatusUnknown Status
SponsorNational University Hospital, Singapore
CountrySingapore
Industrynot industry
Blindingunblinded
Center Typesingel-center RCT
Scopenational RCT
First Patient In2016-05-01
Last Patient Out2020-11-01
Publicationn
Gender %FEMALE
Mean Age18 Years - 99 Years
LLM Classifications (Side-by-Side)
Field CLAUDE
claude-sonnet-4-20250514
Thinking: claude-opus-4-20250514
5529ms / 12235 tok
OPENAI
gpt-4o
Thinking: o3
4565ms / 10424 tok
GLM
glm-5.1
8033ms / 10631 tok
Review
rct_type parallel RCT parallel RCT parallel RCT OK
cancer_status Cancer Cancer Cancer OK
non_cancer_spec N/A N/A N/A OK
setting_patient outpatient outpatient outpatient OK
setting_place other other → other → other
shaky reasoning
✓ Unanimous Initial: other Requery: other — This is a chemotherapy trial conducted at an outpatient cancer center where patients receive IV infusions and oral medications as outpatients, not as hospitalized inpatients. Thinking: other — The intervention involves chemotherapy infusions administered every 2 weeks without requiring hospitalization, indicating outpatient clinic delivery.
other hospital → hospital → other
shaky reasoning
✓ Unanimous Initial: hospital Requery: hospital — The intervention involves dose-dense chemotherapy requiring administration in a clinical setting with access to treatment for side effects like myelosuppression, often provided in a hospital-based setting. Thinking: other — Chemotherapy and oral sunitinib are given in an outpatient cancer clinic (no inpatient admission required), so it is not classified as hospital-based inpatient care.
other other → other
shaky reasoning
✓ Unanimous Initial: other Requery: other — The chemotherapy is delivered in an outpatient or ambulatory care setting every 2 weeks, rather than requiring continuous inpatient hospital admission.
OK
feasibility fully powered RCT fully powered RCT fully powered RCT OK
intervention_pharmacologic yes yes yes OK
intervention_chemo_immuno_radio yes yes yes OK
intervention_complementary no no no OK
intervention_device no no no OK
intervention_psychological no no no OK
intervention_complex no no no OK
intervention_acp no no no OK
intervention_music no no no OK
intervention_screening no no no OK
intervention_palliative no no no OK
intervention_education no no no OK
intervention_digital no no no OK
intervention_other no no no OK
outcome_symptom no no no OK
outcome_qol no no no OK
outcome_dignity no no no OK
outcome_cost no no no OK
outcome_other yes yes yes OK
pharmacologic_sub chemotherapy chemotherapy chemotherapy OK
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