| Protocol ID | NCT02790580 |
| Registration Date | 2016-06-06 |
| Status | Unknown Status |
| Sponsor | National University Hospital, Singapore |
| Country | Singapore |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2016-05-01 |
| Last Patient Out | 2020-11-01 |
| Publication | n |
| Gender % | FEMALE |
| Mean Age | 18 Years - 99 Years |
NCT02790580
Dose-dense Doxorubicin/Cyclophosphamide With Intermittent Low-dose Sunitinib as Neoadjuvant or First-line Palliative Treatment of Newly Diagnosed HER2 Negative Breast Cancer Patients With Measurable Primary Breast Tumor
| Field |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 5529ms / 12235 tok |
OPENAI
gpt-4o Thinking: o3 4565ms / 10424 tok |
GLM
glm-5.1 8033ms / 10631 tok |
Review |
|---|---|---|---|---|
| rct_type | parallel RCT | parallel RCT | parallel RCT | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place |
other
other → other → other
shaky reasoning✓ Unanimous
Initial: other
Requery: other — This is a chemotherapy trial conducted at an outpatient cancer center where patients receive IV infusions and oral medications as outpatients, not as hospitalized inpatients.
Thinking: other — The intervention involves chemotherapy infusions administered every 2 weeks without requiring hospitalization, indicating outpatient clinic delivery.
|
other
hospital → hospital → other
shaky reasoning✓ Unanimous
Initial: hospital
Requery: hospital — The intervention involves dose-dense chemotherapy requiring administration in a clinical setting with access to treatment for side effects like myelosuppression, often provided in a hospital-based setting.
Thinking: other — Chemotherapy and oral sunitinib are given in an outpatient cancer clinic (no inpatient admission required), so it is not classified as hospital-based inpatient care.
|
other
other → other
shaky reasoning✓ Unanimous
Initial: other
Requery: other — The chemotherapy is delivered in an outpatient or ambulatory care setting every 2 weeks, rather than requiring continuous inpatient hospital admission.
|
OK |
| feasibility | fully powered RCT | fully powered RCT | fully powered RCT | OK |
| intervention_pharmacologic | yes | yes | yes | OK |
| intervention_chemo_immuno_radio | yes | yes | yes | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | no | no | no | OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | chemotherapy | chemotherapy | chemotherapy | OK |