NCT02877368

Sarcopenia in Patients With Gastrointestinal Stromal Tumours

Extracted Fields (from Registry)
Protocol IDNCT02877368
Registration Date2016-08-24
Statuscompleted
SponsorCHU de Reims
CountryFrance
Industrynot industry
Blindingunblinded
Center Typesingel-center RCT
Scopenational RCT
First Patient In2014-05-01
Last Patient Out2014-10-01
Publicationn
Gender %ALL
Mean Age18 Years -
LLM Classifications (Side-by-Side)
Field GLM
glm-5.1
9691ms / 8641 tok
CLAUDE
claude-sonnet-4-20250514
Thinking: claude-opus-4-20250514
4949ms / 9912 tok
OPENAI
gpt-4o
Thinking: o3
5906ms / 8482 tok
Review
rct_type N/A N/A N/A OK
cancer_status Cancer Cancer Cancer OK
non_cancer_spec N/A N/A N/A OK
setting_patient outpatient outpatient outpatient OK
setting_place other hospital
shaky reasoning
✓ Unanimous Initial: hospital
other other
shaky reasoning
✓ Unanimous Initial: other
other hospital → other
shaky reasoning
✓ Unanimous Initial: hospital Requery: other — The trial does not specify a distinct location for intervention delivery, potentially involving outpatient or community settings as it involves routine CT scans for sarcopenia and imatinib, which do not require hospitalization.
OK
feasibility N/A N/A N/A OK
intervention_pharmacologic no no no OK
intervention_chemo_immuno_radio no no no OK
intervention_complementary no no no OK
intervention_device no no no OK
intervention_psychological no no no OK
intervention_complex no no no OK
intervention_acp no no no OK
intervention_music no no no OK
intervention_screening no no no OK
intervention_palliative no no no OK
intervention_education no no no OK
intervention_digital no no no OK
intervention_other no no → no
shaky reasoning
✓ Unanimous Initial: no Requery: no — The intervention involves computed tomography (CT) scans for diagnostic/screening purposes, which falls under the screening category.
no yes → no → no
shaky reasoning
✓ Unanimous Initial: yes Requery: no — This is an observational study using computed tomography imaging for measurement purposes, which falls under the screening/diagnostic category rather than being a therapeutic intervention. Thinking: no — The CT scan is a screening/assessment tool used to evaluate sarcopenia, fitting the screening category.
no yes → yes → no
shaky reasoning
✓ Unanimous Initial: yes Requery: yes — The use of computed tomography (CT) scans as a non-invasive imaging technique for evaluating sarcopenia does not fit into the specified categories and aligns with environmental modifications. Thinking: no — The only intervention is computed tomography imaging, which falls under the screening/diagnostic category.
OK
outcome_symptom yes yes
shaky reasoning
✓ Unanimous Initial: yes
yes no → yes
shaky reasoning
✓ Unanimous Initial: no Requery: yes — The secondary outcome measures imatinib-induced toxicities including specific symptoms like nausea, diarrhea, vomiting, asthenia, muscle cramps, and arthralgia graded by NCI Common Toxicity Criteria.
yes yes → yes
shaky reasoning
✓ Unanimous Initial: yes Requery: yes — The secondary outcomes explicitly list symptoms such as nausea, pruritus, diarrhea, vomiting, asthenia, and muscle cramps, which are direct assessments of symptoms.
OK
outcome_qol no no no OK
outcome_dignity no no no OK
outcome_cost no no no OK
outcome_other yes yes → no
shaky reasoning
✓ Unanimous Initial: yes Requery: no — The outcomes (sarcopenia and imatinib-induced toxicities) fit into symptom/medical categories rather than the specified other categories like caregiver outcomes or survival.
yes yes → no → yes
shaky reasoning
✓ Unanimous Initial: yes Requery: no — All outcomes (sarcopenia assessment and imatinib-induced toxicities) are clinical/physiological measurements that fall under symptom/adverse event categories rather than other palliative care outcomes. Thinking: yes — Outcomes measure sarcopenia (muscle mass index) and drug toxicities, not symptom relief, quality of life, dignity, or cost.
yes no → yes → yes
shaky reasoning
✓ Unanimous Initial: no Requery: yes — The trial includes an assessment of sarcopenia, which does not fall under symptom/QoL/dignity/cost categories. Thinking: yes — Primary outcome is change in sarcopenia (muscle mass), which is a physiological/body‐composition metric not covered by symptom, QoL, dignity, or cost categories.
OK
pharmacologic_sub N/A N/A N/A OK
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