| Protocol ID | NCT03348150 |
| Registration Date | 2017-11-20 |
| Status | active, not recruiting |
| Sponsor | The Netherlands Cancer Institute |
| Country | Netherlands |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2017-10-01 |
| Last Patient Out | 2027-10-01 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT03348150
Treatment of Peritoneal Dissemination in Stomach Cancer Patients With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC).
| Field |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 6809ms / 10961 tok |
OPENAI
gpt-4o Thinking: o3 5648ms / 9391 tok |
GLM
glm-5.1 8415ms / 9541 tok |
Review |
|---|---|---|---|---|
| rct_type | parallel RCT | parallel RCT | parallel RCT | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient |
mixed
inpatient → inpatient → mixed
shaky reasoning✓ Unanimous
Initial: inpatient
Requery: inpatient — The experimental arm involves major surgical procedures (gastrectomy, cytoreductive surgery, and HIPEC) which require hospitalization and overnight stays for perioperative care.
Thinking: mixed — The experimental arm involves major surgery (gastrectomy + cytoreductive surgery + HIPEC) requiring hospitalization, while the control arm involves palliative systemic chemotherapy which is typically delivered in an outpatient setting.
|
mixed
outpatient → inpatient → mixed
shaky reasoning✓ Unanimous
Initial: outpatient
Requery: inpatient — The interventions involve surgical procedures and hyperthermic intraperitoneal chemotherapy, which require hospitalization and continuous monitoring.
Thinking: mixed — One arm requires hospitalization for gastrectomy with HIPEC while the other arm receives systemic chemotherapy typically given in the outpatient setting.
|
inpatient | – |
| setting_place | hospital | hospital | hospital | OK |
| feasibility | fully powered RCT | fully powered RCT | fully powered RCT | OK |
| intervention_pharmacologic | yes | yes | yes | OK |
| intervention_chemo_immuno_radio | yes | yes | yes | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | yes | yes | yes | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other |
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The intervention includes cytoreductive surgery (surgical procedure) and hyperthermic intraperitoneal chemotherapy with oxaliplatin and docetaxel (chemotherapy), which falls under the chemo/immuno/radio category.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The intervention involves Hyperthermic Intraperitoneal Chemotherapy (HIPEC), which fits into the chemo category.
|
no | OK |
| outcome_symptom | no | no | no | OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | yes | yes | yes | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | chemotherapy | chemotherapy | chemotherapy | OK |