NCT03592771

✓ Unanimous Initial: no

✓ Unanimous Initial: yes Requery: yes — The intervention combines multiple distinct components including behavioral (app-based symptom monitoring), technological (electronic health record integration with care team alerts), and educational (tailored feedback messages with symptom-specific educational materials and coping strategies) that work together to improve adherence and symptom management.

✓ Unanimous Initial: no Requery: yes — The intervention combines behavioral components (web app usage) and educational components (tailored feedback), which interact to improve medication adherence and symptom management.

✓ Unanimous Initial: no Requery: no — The trial primarily tests a web-enabled app for symptom monitoring and communication rather than focusing on patient or provider education as a primary component.

✓ Unanimous Initial: yes Requery: no — The primary intervention is a behavioral app-based communication system for symptom monitoring and adherence tracking, not an educational program, though some tailored feedback includes educational materials as a secondary component.

✓ Unanimous Initial: yes Requery: no — The primary component of the trial is a communication app to enhance adherence to endocrine therapy, focusing on improving patient-provider communication and symptom management, not primarily on education.

✓ Unanimous Initial: yes Requery: yes — The study explicitly evaluates costs, specifically mentioning 'resource use-related costs' in the detailed description to help achieve the 'Triple Aim' of reducing costs while improving outcomes.

✓ Unanimous Initial: no Requery: yes — The study explicitly states it will evaluate costs and resource use-related costs as part of achieving the 'Triple Aim' to reduce costs while improving health outcomes.

✓ Unanimous Initial: yes Requery: yes — The study evaluates the impact of the intervention on resource use-related costs, fitting the criteria for cost analysis.

✓ Unanimous Initial: yes Requery: yes — The primary outcome measures medication adherence, which is not covered by the symptom/QoL/dignity/cost categories.

✓ Unanimous Initial: yes Requery: no — All outcomes focus on symptom management (Endocrine Symptom Subscale, PROMIS Self-Efficacy for Managing Symptoms), quality of life measures (SF-12 Physical and Mental Component Summary scores), and medication adherence which relates to symptom management - no outcomes measure caregiver impacts, communication quality, goal-concordant care, survival, or other categories outside symptom/QoL domains. Thinking: yes — The primary outcome is medication adherence and the study also mentions communication quality, which are not covered by symptom/QoL/dignity/cost categories.

✓ Unanimous Initial: no Requery: yes — The trial includes outcomes related to patient-provider communication, which are not covered by symptom, QoL, dignity, or cost categories. Thinking: yes — Primary outcome is medication adherence, an outcome outside symptom, QoL, dignity or cost categories.