| Protocol ID | NCT03657121 |
| Registration Date | 2018-09-04 |
| Status | completed |
| Sponsor | Northumbria Healthcare NHS Foundation Trust |
| Country | United Kingdom |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | multicenter RCT |
| Scope | national RCT |
| First Patient In | 2019-01-16 |
| Last Patient Out | 2020-12-18 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 35 Years - |
NCT03657121
COPD: Comparison of Existing Prognostic Tools for 1 Year Mortality and Assessment of Symptom Burden to Facilitate Advance Care Planning
| Field |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 6065ms / 13119 tok |
OPENAI
gpt-4o Thinking: o3 4736ms / 11303 tok |
GLM
glm-5.1 12371ms / 11523 tok |
Review |
|---|---|---|---|---|
| rct_type | N/A | N/A | N/A | OK |
| cancer_status | non-cancer | non-cancer | non-cancer | OK |
| non_cancer_spec | respiratory | respiratory | respiratory | OK |
| setting_patient |
inpatient
mixed → inpatient
shaky reasoning✓ Unanimous
Initial: mixed
Requery: inpatient — The study recruits patients who are admitted to the hospital with COPD exacerbations requiring hospitalization, and the data collection occurs during their hospital admission.
|
inpatient
inpatient → inpatient
shaky reasoning✓ Unanimous
Initial: inpatient
Requery: inpatient — The study involves patients who have been admitted to the hospital with an exacerbation of COPD and includes follow-up assessments over a year, indicating the intervention and assessments are delivered during hospitalization.
|
inpatient
inpatient → inpatient
shaky reasoning✓ Unanimous
Initial: inpatient
Requery: inpatient — The study explicitly enrolls patients who are admitted to the hospital with an acute exacerbation of COPD (ECOPD), collecting baseline data on the hospital wards prior to discharge.
|
OK |
| setting_place | hospital | hospital | hospital | OK |
| feasibility | N/A | N/A | N/A | OK |
| intervention_pharmacologic | no | no | no | OK |
| intervention_chemo_immuno_radio | no | no | no | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp |
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — This is an observational study that aims to develop and validate prognostic tools to facilitate advance care planning rather than implementing ACP interventions directly - it measures outcomes related to identifying patients who would benefit from ACP but does not provide structured ACP conversations or processes.
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The study focuses on prognostic tools for COPD mortality prediction and symptom assessment, with ACP mentioned incidentally but not as a core component of the intervention.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — This is an observational study focused on validating prognostic tools and assessing symptom burden to facilitate future advance care planning, but it does not administer ACP conversations or interventions as a core component.
|
OK |
| intervention_music | no | no | no | OK |
| intervention_screening |
no
no → no → no
shaky reasoning✗ No consensus
Initial: no
Requery: no — This is an observational study comparing the accuracy of existing prognostic tools rather than testing screening as an intervention - the tools are being evaluated as predictive instruments, not implemented as screening interventions.
Thinking: no — This study compares the accuracy of prognostic tools for predicting mortality, not testing screening as an intervention to improve outcomes.
|
yes
yes → yes → yes
shaky reasoning✗ No consensus
Initial: yes
Requery: yes — The trial is testing and comparing prognostic tools for predicting mortality, which aligns with screening to identify patients at risk for palliative care needs.
Thinking: yes — The study’s main purpose is to compare multiple prognostic/screening tools (e.g., SPICT, PEARL, BODEX) for identifying COPD patients needing advance care planning, so the screening tools themselves are the intervention being evaluated.
|
no
no → no
shaky reasoning✗ No consensus
Initial: no
Requery: no — This is an observational study comparing the accuracy and ease of use of various existing prognostic tools, rather than experimentally testing a screening intervention.
|
|
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | yes | yes | yes | OK |
| outcome_qol | yes | yes | yes | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | yes | yes | yes | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | N/A | N/A | N/A | OK |