| Protocol ID | NCT03701659 |
| Registration Date | 2018-10-10 |
| Status | Unknown Status |
| Sponsor | The Third Xiangya Hospital of Central South University |
| Country | – |
| Industry | not industry |
| Blinding | blinded |
| Center Type | – |
| Scope | – |
| First Patient In | 2018-12-01 |
| Last Patient Out | 2025-11-30 |
| Publication | n |
| Gender % | MALE |
| Mean Age | 50 Years - 79 Years |
NCT03701659
A Prospective, Multi-center Clinical Study of Palliative Transurethral Plasma Kinetic Resection of Prostate (TUPKRP) Combined With Endocrine Therapy for Advanced Prostate Cancer Complicated With Severe Lower Urinary Tract Symptoms
| Field |
GLM
glm-5.1 9271ms / 10342 tok |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 5710ms / 11789 tok |
OPENAI
gpt-4o Thinking: o3 3147ms / 10165 tok |
Review |
|---|---|---|---|---|
| rct_type | parallel RCT | parallel RCT | parallel RCT | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient |
mixed
mixed → mixed
shaky reasoning✗ No consensus
Initial: mixed
Requery: mixed — The trial involves a surgical intervention (TUPKRP) requiring inpatient admission, combined with ongoing outpatient endocrine therapy (MAB), creating both inpatient and outpatient phases of the intervention.
|
inpatient
inpatient → mixed → outpatient
shaky reasoning✗ No consensus
Initial: inpatient
Requery: mixed — The study includes both TUPKRP (transurethral plasma kinetic resection of prostate) which is a surgical procedure requiring hospitalization, and ongoing outpatient endocrine therapy with follow-up visits for assessments.
Thinking: outpatient — The trial involves TUPKRP surgery and endocrine therapy with follow-up visits at 3, 6, and 12 months, without mention of hospital admission or overnight stays.
|
outpatient
outpatient → outpatient → mixed
shaky reasoning✗ No consensus
Initial: outpatient
Requery: outpatient — The intervention involves a transurethral procedure and endocrine therapy, which are typically performed on an outpatient basis.
Thinking: mixed — One arm receives inpatient transurethral prostate surgery while the control arm gets outpatient endocrine therapy only, so the study delivers interventions in both inpatient and outpatient settings.
|
|
| setting_place |
hospital
hospital → hospital
shaky reasoning✓ Unanimous
Initial: hospital
Requery: hospital — The intervention involves a surgical procedure (TUPKRP) under anesthesia, which requires hospital admission and an operating room setting.
|
hospital
hospital → hospital
shaky reasoning✓ Unanimous
Initial: hospital
Requery: hospital — The intervention involves surgical procedures (TUPKRP - transurethral plasma kinetic resection of prostate) which require hospitalization and inpatient care for the procedure and recovery.
|
hospital
other → hospital
shaky reasoning✓ Unanimous
Initial: other
Requery: hospital — The intervention involves transurethral plasma kinetic resection of the prostate, a surgical procedure performed on patients, indicating a hospital setting for the delivery of this treatment.
|
OK |
| feasibility | fully powered RCT | fully powered RCT | fully powered RCT | OK |
| intervention_pharmacologic | yes | yes | yes | OK |
| intervention_chemo_immuno_radio | no | no | no | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | yes | yes | yes | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative |
no
yes
shaky reasoning✓ Unanimous
Initial: yes
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The intervention is a surgical procedure (TUPKRP) combined with endocrine therapy for prostate cancer - while 'palliative' appears in the title to describe the surgical approach, the actual intervention being tested is the surgical/medical treatment itself, not palliative care consultation or service delivery.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The intervention involves surgical and endocrine therapies in a palliative setting, but does not test palliative care itself as an intervention.
|
OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other |
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The trial utilizes pharmacologic (endocrine/Drug), palliative (palliative TUPKRP), and chemo/immuno/radio (endocrine therapy/cancer treatment) interventions.
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The intervention includes both a surgical procedure (TUPKRP) which is a device-based intervention and pharmacologic endocrine therapy (MAB), so it does not qualify as the residual 'other' category.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The intervention includes palliative TUPKRP, which is a surgical procedure and hormonal endocrine therapy. Both are classified under device/surgery and pharmacologic interventions, respectively.
|
OK |
| outcome_symptom | yes | yes | yes | OK |
| outcome_qol | yes | yes | yes | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | other | other | other | OK |