NCT04202523

✓ Unanimous Initial: hospital

✓ Unanimous Initial: hospital Requery: hospital — The intervention involves radiofrequency ablation and radiotherapy procedures that require specialized medical equipment and facilities, indicating inpatient or hospital-based treatment delivery.

✓ Unanimous Initial: other Requery: hospital — The intervention involves radiofrequency ablation and radiotherapy which require hospital-based facilities for delivery and would take place in a hospital setting.

✓ Unanimous Initial: feasibility RCT Requery: feasibility RCT — Despite being designated as a Phase III trial, the small sample size of 50 (n≤60) indicates it is likely a pilot or feasibility study rather than a fully powered trial for clinical effectiveness.

✓ Unanimous Initial: feasibility RCT Requery: feasibility RCT — The study has a small enrollment of 50 participants and lacks specific primary endpoint definitions (DFS is listed as 'N/A'), suggesting this is likely a pilot study to assess the feasibility of combining radiotherapy with radiofrequency ablation.

✓ Unanimous Initial: fully powered RCT Requery: feasibility RCT — The trial has an enrollment of 50 participants and is likely focused on feasibility of combined treatments due to the lack of detailed clinical outcomes and primary outcomes not mentioned.

✓ Unanimous Initial: yes Requery: no — Combining radiotherapy and radiofrequency ablation represents the combination of two procedural/surgical modalities rather than distinct categories like pharmacologic and psychological, which does not meet the criteria for a complex intervention.

✓ Unanimous Initial: yes Requery: no — This combines two physical treatment modalities (radiotherapy and radiofrequency ablation) from the same category of local tumor destruction techniques, rather than combining distinct intervention types that interact differently. Thinking: no — Combining two procedural/device-based local tumor treatments (RFA and radiotherapy) represents similar modalities, not fundamentally different intervention categories.

✓ Unanimous Initial: no Requery: yes — The trial involves the combination of radiotherapy and radiofrequency ablation, which are two distinct treatment modalities from different intervention categories, thus classifying it as a complex intervention. Thinking: no — Radiotherapy and radiofrequency ablation are both procedural/physical treatments within the same category, so the intervention is single-modality rather than multi-component across different categories.