| Protocol ID | NCT04287829 |
| Registration Date | 2020-02-27 |
| Status | active, not recruiting |
| Sponsor | The Netherlands Cancer Institute |
| Country | Netherlands |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2021-03-01 |
| Last Patient Out | 2026-03-05 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT04287829
PEMbrolizumab Plus Lenvatinib In Second Line And Third Line Malignant Pleural MEsotheLiomA Patients(PEMMELA)
| Field |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 5507ms / 11024 tok |
OPENAI
gpt-4o Thinking: o3 4207ms / 9477 tok |
GLM
glm-5.1 6726ms / 9660 tok |
Review |
|---|---|---|---|---|
| rct_type | N/A | N/A | N/A | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place |
other
other → other → other
shaky reasoning✓ Unanimous
Initial: other
Requery: other — This is a cancer treatment study involving intravenous pembrolizumab infusions and oral lenvatinib capsules delivered at an outpatient cancer center/clinic rather than requiring hospital admission.
Thinking: other — The intervention involves outpatient IV infusions every 3 weeks and oral medication, indicating delivery in an outpatient clinic rather than requiring hospitalization.
|
other
hospital → hospital → other
shaky reasoning✓ Unanimous
Initial: hospital
Requery: hospital — The intervention involves intravenous infusions which are typically administered in a hospital setting.
Thinking: other — Pembrolizumab infusions and oral lenvatinib are given in an outpatient oncology clinic at a cancer institute, not requiring hospital admission.
|
hospital | – |
| feasibility | fully powered RCT | fully powered RCT | N/A | – |
| intervention_pharmacologic | yes | yes | yes | OK |
| intervention_chemo_immuno_radio |
yes
yes → yes
shaky reasoning✓ Unanimous
Initial: yes
Requery: yes — The study tests pembrolizumab (a PD-1 checkpoint inhibitor immunotherapy) plus lenvatinib as the active intervention being evaluated.
|
yes
no → yes
shaky reasoning✓ Unanimous
Initial: no
Requery: yes — Pembrolizumab, an immunotherapy drug, is an active component being tested in this trial.
|
yes | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | no | no | no | OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | immunotherapy | immunotherapy | immunotherapy | OK |