NCT04287829

PEMbrolizumab Plus Lenvatinib In Second Line And Third Line Malignant Pleural MEsotheLiomA Patients(PEMMELA)

Extracted Fields (from Registry)
Protocol IDNCT04287829
Registration Date2020-02-27
Statusactive, not recruiting
SponsorThe Netherlands Cancer Institute
CountryNetherlands
Industrynot industry
Blindingunblinded
Center Typesingel-center RCT
Scopenational RCT
First Patient In2021-03-01
Last Patient Out2026-03-05
Publicationn
Gender %ALL
Mean Age18 Years -
LLM Classifications (Side-by-Side)
Field CLAUDE
claude-sonnet-4-20250514
Thinking: claude-opus-4-20250514
5507ms / 11024 tok
OPENAI
gpt-4o
Thinking: o3
4207ms / 9477 tok
GLM
glm-5.1
6726ms / 9660 tok
Review
rct_type N/A N/A N/A OK
cancer_status Cancer Cancer Cancer OK
non_cancer_spec N/A N/A N/A OK
setting_patient outpatient outpatient outpatient OK
setting_place other other → other → other
shaky reasoning
✓ Unanimous Initial: other Requery: other — This is a cancer treatment study involving intravenous pembrolizumab infusions and oral lenvatinib capsules delivered at an outpatient cancer center/clinic rather than requiring hospital admission. Thinking: other — The intervention involves outpatient IV infusions every 3 weeks and oral medication, indicating delivery in an outpatient clinic rather than requiring hospitalization.
other hospital → hospital → other
shaky reasoning
✓ Unanimous Initial: hospital Requery: hospital — The intervention involves intravenous infusions which are typically administered in a hospital setting. Thinking: other — Pembrolizumab infusions and oral lenvatinib are given in an outpatient oncology clinic at a cancer institute, not requiring hospital admission.
hospital
feasibility fully powered RCT fully powered RCT N/A
intervention_pharmacologic yes yes yes OK
intervention_chemo_immuno_radio yes yes → yes
shaky reasoning
✓ Unanimous Initial: yes Requery: yes — The study tests pembrolizumab (a PD-1 checkpoint inhibitor immunotherapy) plus lenvatinib as the active intervention being evaluated.
yes no → yes
shaky reasoning
✓ Unanimous Initial: no Requery: yes — Pembrolizumab, an immunotherapy drug, is an active component being tested in this trial.
yes OK
intervention_complementary no no no OK
intervention_device no no no OK
intervention_psychological no no no OK
intervention_complex no no no OK
intervention_acp no no no OK
intervention_music no no no OK
intervention_screening no no no OK
intervention_palliative no no no OK
intervention_education no no no OK
intervention_digital no no no OK
intervention_other no no no OK
outcome_symptom no no no OK
outcome_qol no no no OK
outcome_dignity no no no OK
outcome_cost no no no OK
outcome_other yes yes yes OK
pharmacologic_sub immunotherapy immunotherapy immunotherapy OK
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