| Protocol ID | NCT04385160 |
| Registration Date | 2020-05-12 |
| Status | completed |
| Sponsor | FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS |
| Country | Bulgaria, Croatia, France, Germany, Italy, Poland, Spain, United Kingdom, United States |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | multicenter RCT |
| Scope | multinational RCT |
| First Patient In | 2020-05-13 |
| Last Patient Out | 2022-08-31 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT04385160
Myeloproliferative Neoplasms (MPN) and COVID-19
| Field |
OPENAI
gpt-4o 4451ms / 8881 tok |
CLAUDE
claude-sonnet-4-20250514 4466ms / 10304 tok |
GLM
glm-5.1 9128ms / 9030 tok |
Review |
|---|---|---|---|---|
| rct_type | N/A | N/A | N/A | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | mixed | mixed | mixed | OK |
| setting_place |
other
hospital → other
shaky reasoning✓ Unanimous
Initial: hospital
Requery: other — The study involves follow-up of MPN patients diagnosed with COVID-19 in multiple centers, collecting data retrospectively and prospectively, indicating a mixture of settings including outpatient and potential hospital data collection, but no specific inpatient intervention delivery.
|
other
other → other
shaky reasoning✓ Unanimous
Initial: other
Requery: other — This is an observational study collecting data on MPN patients with COVID-19 across multiple European centers without specifying a single intervention delivery location, making it a mixed/community-based data collection study.
|
other
hospital → other
shaky reasoning✓ Unanimous
Initial: hospital
Requery: other — This is a multicenter observational study tracking outcomes across various settings (including outpatient and inpatient), rather than delivering a specific clinical intervention at a single fixed location.
|
OK |
| feasibility | N/A | N/A | N/A | OK |
| intervention_pharmacologic | no | no | no | OK |
| intervention_chemo_immuno_radio | no | no | no | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom |
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The trial focuses on thrombotic events and disease outcomes rather than specific symptoms or symptom scales.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — This observational study focuses on clinical outcomes like thrombotic events, pulmonary embolism, mortality, and treatment interventions, but does not measure specific symptoms using validated symptom assessment instruments.
|
no
yes
shaky reasoning✓ Unanimous
Initial: yes
|
OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost |
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The clinical trial focuses on clinical outcomes, patient characteristics, and mortality rates without any specific mention of cost-effectiveness or healthcare utilization.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The study measures clinical outcomes like thrombotic events, mortality, and disease progression without any cost-effectiveness analysis, healthcare utilization assessment, or cost-related measurements.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The clinical outcomes focus on clinical events like thrombosis, mortality, and ICU admission without measuring healthcare utilization or economic costs.
|
OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | N/A | N/A | N/A | OK |