| Protocol ID | NCT04553458 |
| Registration Date | 2020-09-17 |
| Status | completed |
| Sponsor | Sohag University |
| Country | – |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | – |
| Scope | – |
| First Patient In | 2015-06-01 |
| Last Patient Out | 2020-06-01 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT04553458
Factors Affecting Post-treatment Outcomes in Patients With Hepatocellular Carcinoma
| Field |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 4488ms / 9993 tok |
OPENAI
gpt-4o Thinking: o3 3435ms / 8581 tok |
GLM
glm-5.1 5742ms / 8743 tok |
Review |
|---|---|---|---|---|
| rct_type | N/A | N/A | N/A | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | mixed | mixed | mixed | OK |
| setting_place | hospital | hospital | hospital | OK |
| feasibility | N/A | N/A | N/A | OK |
| intervention_pharmacologic |
no
no → yes → no
shaky reasoning✓ Unanimous
Initial: no
Requery: yes — Multiple drug interventions are listed including chemotherapy, sorafenib, and percutaneous ethanol injection which are pharmacologic treatments.
Thinking: no — This is a retrospective observational study analyzing outcomes from multiple standard treatments, not testing a specific experimental intervention.
|
no
yes → yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: yes — The intervention includes drugs/medications such as Sorafenib, systemic chemotherapy, and percutaneous ethanol injection.
Thinking: no — The study is observational with no experimental intervention arm, so pharmacologic exposure is not being prospectively tested.
|
no | OK |
| intervention_chemo_immuno_radio |
yes
no → yes → yes
shaky reasoning✓ Unanimous
Initial: no
Requery: yes — The study includes systemic chemotherapy, trans-arterial chemoembolization, and sorafenib as active treatment interventions being analyzed for their outcomes in hepatocellular carcinoma patients.
Thinking: yes — The trial includes trans-arterial chemoembolization and systemic chemotherapy as active treatment interventions being tested.
|
yes
yes → yes → yes
shaky reasoning✓ Unanimous
Initial: yes
Requery: yes — The trial includes trance-arterial chemotherapy and systemic chemotherapy as tested interventions.
Thinking: yes — The study evaluates treatments including trans-arterial chemoembolization and systemic chemotherapy, which are chemotherapy interventions.
|
no | – |
| intervention_complementary |
yes
no → yes → yes
shaky reasoning✓ Unanimous
Initial: no
Requery: yes — The study includes Viscum (a herbal remedy) as one of the interventions for hepatocellular carcinoma treatment.
Thinking: yes — The trial includes Viscum as an intervention, which is a herbal remedy commonly used in complementary cancer treatment.
|
yes
yes → yes → yes
shaky reasoning✓ Unanimous
Initial: yes
Requery: yes — The trial includes Viscum, a herbal remedy, which is a complementary modality.
Thinking: yes — Viscum (mistletoe extract) is a herbal remedy, which counts as a complementary modality.
|
no | – |
| intervention_device |
yes
no → yes
shaky reasoning✓ Unanimous
Initial: no
Requery: yes — Radiofrequency ablation involves physical medical device/equipment used for tumor ablation, making this a device-based intervention.
|
yes
yes → yes
shaky reasoning✓ Unanimous
Initial: yes
Requery: yes — Radiofrequency ablation involves a physical device for treatment.
|
no | – |
| intervention_psychological | no | no | no | OK |
| intervention_complex |
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — This is an observational study retrospectively analyzing different single-modality treatments (radiofrequency ablation, liver resection, chemotherapy, etc.) rather than a trial testing a complex intervention with multiple interacting components.
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The trial involves various therapeutic modalities for treating HCC but it does not explicitly combine different types of interventions such as psychological or educational components, hence not a complex intervention.
|
no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | no | no | no | OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub |
N/A
N/A → chemotherapy → other
shaky reasoning✗ No consensus
Initial: N/A
Requery: chemotherapy — The trial includes multiple pharmacologic interventions with cytotoxic agents including trance-arterial chemoembolization, systemic chemotherapy, and ethanol injection which are cytotoxic treatments for hepatocellular carcinoma.
Thinking: other — This observational study includes multiple pharmacologic interventions across different categories (chemotherapy, sorafenib, ethanol injection, phytotherapy) without focusing on a single drug class.
|
chemotherapy
chemotherapy → chemotherapy → chemotherapy
shaky reasoning✗ No consensus
Initial: chemotherapy
Requery: chemotherapy — The intervention involves trans-arterial chemotherapy and systemic chemotherapy, which are cytotoxic agents used for treating cancer.
Thinking: chemotherapy — Interventions include trans-arterial chemoembolization and systemic chemotherapy, which are cytotoxic cancer treatments.
|
N/A |
|