| Protocol ID | NCT05233904 |
| Registration Date | 2022-02-10 |
| Status | Unknown Status |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
| Country | Canada |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2022-06-08 |
| Last Patient Out | 2023-08-01 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT05233904
DART: Diagnostic-CT-Enabled Planning: A Randomized Trial in Palliative Radiation Therapy
| Field |
OPENAI
gpt-4o Thinking: o3 4902ms / 8351 tok |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 4806ms / 9683 tok |
GLM
glm-5.1 6707ms / 8488 tok |
Review |
|---|---|---|---|---|
| rct_type | parallel RCT | parallel RCT | parallel RCT | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place | hospital | hospital | hospital | OK |
| feasibility | feasibility RCT | feasibility RCT | feasibility RCT | OK |
| intervention_pharmacologic | no | no | no | OK |
| intervention_chemo_immuno_radio |
yes
yes → yes → yes
shaky reasoning✗ No consensus
Initial: yes
Requery: yes — Radiation therapy is an active component being tested in this trial.
Thinking: yes — Palliative radiation therapy is the active intervention being evaluated.
|
yes
yes → yes → no
shaky reasoning✗ No consensus
Initial: yes
Requery: yes — This study is testing palliative radiation therapy delivery methods, with radiation therapy being the active treatment intervention being compared between different planning approaches.
Thinking: no — The trial tests different CT planning methods for radiation therapy, not radiation therapy itself - both arms receive the same palliative radiation treatment.
|
no
no → no
shaky reasoning✗ No consensus
Initial: no
Requery: no — The trial evaluates diagnostic-CT-enabled planning as a workflow intervention for radiation therapy, rather than testing the radiation therapy itself as the experimental intervention.
|
|
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative |
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The trial tests a diagnostic-CT-enabled planning method for palliative radiation therapy, not a palliative care intervention.
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — This study compares two different CT planning methods (diagnostic-CT-enabled vs conventional CT simulation) for radiation therapy delivery in palliative care patients, making it a radiologic/procedural intervention rather than palliative care consultation or service delivery.
|
no
no
shaky reasoning✓ Unanimous
Initial: no
|
OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other |
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The trial involves a diagnostic-CT-enabled planning process for palliative radiation therapy, fitting under the category of complex interventions involving combination techniques related to radiation treatment.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The intervention involves diagnostic-CT-enabled planning for radiation therapy treatment, which is a radiotherapy-related intervention that falls under the radio category.
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The trial compares two methods of radiation treatment planning, which falls under the chemo/immuno/radio category.
|
OK |
| outcome_symptom | no | no | no | OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other |
yes
no → yes → yes
shaky reasoning✓ Unanimous
Initial: no
Requery: yes — The primary outcome of 'Time in Centre (TIC) on Treatment Day' relates to feasibility metrics, not symptom/QoL/dignity/cost categories.
Thinking: yes — Primary outcome measures process efficiency (time in centre), a feasibility metric not related to symptoms, QoL, dignity, or cost.
|
yes
yes → no → yes
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The primary outcome 'Time in Centre on Treatment Day' is a feasibility/efficiency metric related to healthcare delivery processes, not a patient-centered outcome like symptoms, quality of life, dignity, or cost.
Thinking: yes — The primary outcome measures time in center (treatment efficiency), which is a feasibility metric rather than symptom/QoL/dignity/cost outcome.
|
yes
yes → yes
shaky reasoning✓ Unanimous
Initial: yes
Requery: yes — The primary outcome measures time efficiency and logistical feasibility (Time in Centre), which falls under feasibility metrics rather than symptom, QoL, dignity, or cost categories.
|
OK |
| pharmacologic_sub | N/A | N/A | N/A | OK |