NCT05415969

✗ No consensus Initial: no Requery: yes — The trial is an observational study focused on identifying the prevalence and severity of a condition and measuring biomarkers, which fits the residual category as it does not involve pharmacologic, device, or other specified active interventions.

✗ No consensus Initial: no Requery: no — This is an observational study focused on identifying prevalence and severity of CKD-associated pruritus through questionnaires and biomarker measurements, which does not constitute an active intervention but rather assessment/screening activities. Thinking: yes — This is an observational assessment study measuring prevalence and biomarkers, not fitting any specified intervention categories.

✗ No consensus Initial: yes Requery: no — The study is observational and focuses on assessing the prevalence and severity of CKD-aP, which does not involve any intervention fitting exercise, nutritional, or environmental categories. Thinking: no — The study’s only intervention is assessing/screening patients to identify prevalence and severity of pruritus, which fits the screening category.

✗ No consensus Initial: yes Requery: yes — The secondary outcomes measure biomarkers (sweat electrolytes and urea) to investigate pathogenesis, which are not covered by symptom, QoL, dignity, or cost categories.

✗ No consensus Initial: yes Requery: no — All outcomes measure symptom severity (pruritus) and associated biomarkers, which fall under the symptom category. Thinking: no — All outcomes measure symptom prevalence/severity (pruritus) or related biomarkers, with no caregiver, communication, survival, or other specified outcomes.

✗ No consensus Initial: no Requery: no — All outcomes focus on symptoms, specifically the prevalence and severity of pruritus, and do not extend to non-symptom categories. Thinking: yes — The trial measures laboratory biomarker outcomes (sweat electrolyte levels) that fall outside symptom, QoL, dignity, or cost domains.