| Protocol ID | NCT06556550 |
| Registration Date | 2024-08-16 |
| Status | recruiting |
| Sponsor | National Medical Research Radiological Centre of the Ministry of Health of Russia |
| Country | Russia |
| Industry | not industry |
| Blinding | blinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2024-05-31 |
| Last Patient Out | 2029-12-31 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT06556550
Stereotactic Radiation Therapy for Oligometastasis (1-5) in Various Tumor Sites in Comparison to Palliative Care of Oligometastatic Tumors.
| Field |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 9443ms / 11455 tok |
OPENAI
gpt-4o Thinking: o3 3562ms / 9896 tok |
GLM
glm-5.1 7217ms / 10082 tok |
Review |
|---|---|---|---|---|
| rct_type | parallel RCT | parallel RCT | parallel RCT | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient |
inpatient
mixed → mixed → inpatient
shaky reasoning✓ Unanimous
Initial: mixed
Requery: mixed — The detailed description explicitly states study periods include both 'inpatient (includes pre-radiation training for up to 3 working days, remote radiation therapy, from one to eight working days)' and outpatient follow-up visits at 3, 6, 9, 12, 18, 24 months.
Thinking: inpatient — The study explicitly describes an 'inpatient' period that includes pre-radiation training and radiation therapy delivery lasting up to 8 working days.
|
inpatient
mixed → inpatient → inpatient
shaky reasoning✓ Unanimous
Initial: mixed
Requery: inpatient — The study involves an 'inpatient' period for delivering radiation therapy as part of the treatment.
Thinking: inpatient — The stereotactic (and comparator) radiation therapy is administered during a defined hospital inpatient period lasting up to several days.
|
inpatient
inpatient
shaky reasoning✓ Unanimous
Initial: inpatient
|
OK |
| setting_place | hospital | hospital | hospital | OK |
| feasibility | fully powered RCT | fully powered RCT | fully powered RCT | OK |
| intervention_pharmacologic |
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The experimental intervention is stereotactic ablative radiation therapy, which is a radiation-based treatment technique, not a drug or medication.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The experimental intervention is stereotactic radiation therapy, which does not involve any pharmacologic agents.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The experimental intervention is stereotactic ablative radiation therapy, a non-pharmacologic procedure, while the listed drug chemotherapy is part of standard of care and background treatment.
|
OK |
| intervention_chemo_immuno_radio | yes | yes | yes | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative | no | no | no | OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | yes | yes | yes | OK |
| outcome_qol | yes | yes | yes | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub |
chemotherapy
chemotherapy → N/A → N/A
shaky reasoning✗ No consensus
Initial: chemotherapy
Requery: N/A — The primary intervention is stereotactic ablative radiation therapy (SABR) compared to palliative radiation therapy, both of which are radiation-based treatments rather than pharmacologic interventions.
Thinking: N/A — The primary intervention being tested is stereotactic radiation therapy, which is a physical modality, not a pharmacologic intervention.
|
N/A
N/A → radiation → chemotherapy
shaky reasoning✗ No consensus
Initial: N/A
Requery: radiation — The clinical trial focuses on the use of stereotactic radiation therapy to treat oligometastatic tumors.
Thinking: chemotherapy — One study arm uses standard cytotoxic chemotherapy drugs for cancer treatment.
|
N/A
N/A → N/A
shaky reasoning✗ No consensus
Initial: N/A
Requery: N/A — The primary intervention being investigated is stereotactic radiation therapy, which is a non-pharmacologic procedure, and chemotherapy is only included as a background standard of care.
|
|