| Protocol ID | NCT06794125 |
| Registration Date | 2025-01-27 |
| Status | recruiting |
| Sponsor | Chris Goodman |
| Country | Canada |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | multicenter RCT |
| Scope | national RCT |
| First Patient In | 2025-09-03 |
| Last Patient Out | 2029-03-01 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - |
NCT06794125
A Phase II/III Randomized Evaluation of Dose-escalation With Esophageal-sparing for Palliation of Intrathoracic Tumours (PREVENT)
| Field |
OPENAI
gpt-4o Thinking: o3 3079ms / 8661 tok |
GLM
glm-5.1 9963ms / 8809 tok |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 4994ms / 10082 tok |
Review |
|---|---|---|---|---|
| rct_type | parallel RCT | parallel RCT | parallel RCT | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place |
other
hospital → hospital → other
shaky reasoning✓ Unanimous
Initial: hospital
Requery: hospital — The intervention involves the delivery of radiation therapy, which typically requires the use of hospital-based equipment and infrastructure.
Thinking: other — Radiation therapy is provided in an outpatient cancer/radiotherapy clinic, not requiring inpatient hospital admission.
|
other
other
shaky reasoning✓ Unanimous
Initial: other
|
other
other → other → other
shaky reasoning✓ Unanimous
Initial: other
Requery: other — This is a radiation therapy study delivered at outpatient radiation oncology clinics, which are typically ambulatory care settings rather than requiring inpatient hospitalization.
Thinking: other — Palliative radiation therapy delivered as outpatient treatment sessions over 5-10 fractions, not requiring hospital admission.
|
OK |
| feasibility | fully powered RCT | fully powered RCT | fully powered RCT | OK |
| intervention_pharmacologic | no | no | no | OK |
| intervention_chemo_immuno_radio | yes | yes | yes | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | no | no | no | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative |
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The trial evaluates different radiation therapy approaches for palliative care settings but does not test palliative care as the intervention itself.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The trial is a radiation therapy study (dose-escalated vs. standard) for symptom palliation in lung cancer, making palliative care the setting rather than the intervention being tested.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — This trial compares two different radiation therapy techniques (standard vs. dose-escalated esophageal-sparing) for treating intrathoracic tumors, making radiation therapy the intervention being tested rather than palliative care itself.
|
OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | no | no | no | OK |
| outcome_qol | yes | yes | yes | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | N/A | N/A | N/A | OK |