NCT06794125

A Phase II/III Randomized Evaluation of Dose-escalation With Esophageal-sparing for Palliation of Intrathoracic Tumours (PREVENT)

Extracted Fields (from Registry)
Protocol IDNCT06794125
Registration Date2025-01-27
Statusrecruiting
SponsorChris Goodman
CountryCanada
Industrynot industry
Blindingunblinded
Center Typemulticenter RCT
Scopenational RCT
First Patient In2025-09-03
Last Patient Out2029-03-01
Publicationn
Gender %ALL
Mean Age18 Years -
LLM Classifications (Side-by-Side)
Field OPENAI
gpt-4o
Thinking: o3
3079ms / 8661 tok
GLM
glm-5.1
9963ms / 8809 tok
CLAUDE
claude-sonnet-4-20250514
Thinking: claude-opus-4-20250514
4994ms / 10082 tok
Review
rct_type parallel RCT parallel RCT parallel RCT OK
cancer_status Cancer Cancer Cancer OK
non_cancer_spec N/A N/A N/A OK
setting_patient outpatient outpatient outpatient OK
setting_place other hospital → hospital → other
shaky reasoning
✓ Unanimous Initial: hospital Requery: hospital — The intervention involves the delivery of radiation therapy, which typically requires the use of hospital-based equipment and infrastructure. Thinking: other — Radiation therapy is provided in an outpatient cancer/radiotherapy clinic, not requiring inpatient hospital admission.
other other
shaky reasoning
✓ Unanimous Initial: other
other other → other → other
shaky reasoning
✓ Unanimous Initial: other Requery: other — This is a radiation therapy study delivered at outpatient radiation oncology clinics, which are typically ambulatory care settings rather than requiring inpatient hospitalization. Thinking: other — Palliative radiation therapy delivered as outpatient treatment sessions over 5-10 fractions, not requiring hospital admission.
OK
feasibility fully powered RCT fully powered RCT fully powered RCT OK
intervention_pharmacologic no no no OK
intervention_chemo_immuno_radio yes yes yes OK
intervention_complementary no no no OK
intervention_device no no no OK
intervention_psychological no no no OK
intervention_complex no no no OK
intervention_acp no no no OK
intervention_music no no no OK
intervention_screening no no no OK
intervention_palliative no yes → no
shaky reasoning
✓ Unanimous Initial: yes Requery: no — The trial evaluates different radiation therapy approaches for palliative care settings but does not test palliative care as the intervention itself.
no no → no
shaky reasoning
✓ Unanimous Initial: no Requery: no — The trial is a radiation therapy study (dose-escalated vs. standard) for symptom palliation in lung cancer, making palliative care the setting rather than the intervention being tested.
no no → no
shaky reasoning
✓ Unanimous Initial: no Requery: no — This trial compares two different radiation therapy techniques (standard vs. dose-escalated esophageal-sparing) for treating intrathoracic tumors, making radiation therapy the intervention being tested rather than palliative care itself.
OK
intervention_education no no no OK
intervention_digital no no no OK
intervention_other no no no OK
outcome_symptom no no no OK
outcome_qol yes yes yes OK
outcome_dignity no no no OK
outcome_cost no no no OK
outcome_other yes yes yes OK
pharmacologic_sub N/A N/A N/A OK
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