| Protocol ID | NCT06827054 |
| Registration Date | 2025-02-14 |
| Status | not yet recruiting |
| Sponsor | Roswell Park Cancer Institute |
| Country | United States |
| Industry | not industry |
| Blinding | unblinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2026-05-15 |
| Last Patient Out | 2027-05-05 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 18 Years - 75 Years |
NCT06827054
Low-Dose Psilocybin Therapy for Palliative Care Patients With Chronic Cancer Pain Requiring Opioids
| Field |
GLM
glm-5.1 9712ms / 11375 tok |
CLAUDE
claude-sonnet-4-20250514 6486ms / 13017 tok |
OPENAI
gpt-4o 6165ms / 11185 tok |
Review |
|---|---|---|---|---|
| rct_type | N/A | N/A | N/A | OK |
| cancer_status | Cancer | Cancer | Cancer | OK |
| non_cancer_spec | N/A | N/A | N/A | OK |
| setting_patient | outpatient | outpatient | outpatient | OK |
| setting_place | other | other | other | OK |
| feasibility | feasibility RCT | feasibility RCT | feasibility RCT | OK |
| intervention_pharmacologic | yes | yes | yes | OK |
| intervention_chemo_immuno_radio | no | no | no | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | yes | yes | yes | OK |
| intervention_complex | yes | yes | yes | OK |
| intervention_acp | no | no | no | OK |
| intervention_music | no | no | no | OK |
| intervention_screening | no | no | no | OK |
| intervention_palliative |
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The intervention being tested is low-dose psilocybin with psychotherapy for pain management, with palliative care serving as the patient population and setting rather than the intervention itself.
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — This is a drug trial testing psilocybin with psychotherapy for chronic cancer pain in palliative care patients - the intervention is pharmacologic/behavioral therapy delivered in a palliative care setting, not palliative care itself.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The trial tests the effects of psilocybin and psychotherapy on pain in palliative care patients, not palliative care itself as the intervention.
|
OK |
| intervention_education | no | no | no | OK |
| intervention_digital | no | no | no | OK |
| intervention_other | no | no | no | OK |
| outcome_symptom | yes | yes | yes | OK |
| outcome_qol | no | no | no | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | no | no | no | OK |
| outcome_other | yes | yes | yes | OK |
| pharmacologic_sub | controlled substances | controlled substances | controlled substances | OK |