| Protocol ID | NCT07157982 |
| Registration Date | 2025-09-05 |
| Status | not yet recruiting |
| Sponsor | Johns Hopkins University |
| Country | United States |
| Industry | not industry |
| Blinding | blinded |
| Center Type | singel-center RCT |
| Scope | national RCT |
| First Patient In | 2026-05-01 |
| Last Patient Out | 2028-03-01 |
| Publication | n |
| Gender % | ALL |
| Mean Age | 50 Years - |
NCT07157982
Living With Multimorbidity: Care Coordination and Symptom Management Program (COORDINATE)
| Field |
CLAUDE
claude-sonnet-4-20250514 Thinking: claude-opus-4-20250514 10637ms / 11060 tok |
OPENAI
gpt-4o Thinking: o3 3121ms / 9645 tok |
GLM
glm-5.1 7584ms / 9790 tok |
Review |
|---|---|---|---|---|
| rct_type | parallel RCT | parallel RCT | parallel RCT | OK |
| cancer_status | non-cancer | non-cancer | non-cancer | OK |
| non_cancer_spec |
N/A
N/A → N/A → N/A
shaky reasoning✓ Unanimous
Initial: N/A
Requery: N/A — The study targets older adults with multimorbidity (two or more chronic conditions) which is too general and mixed to fit into any specific disease category.
Thinking: N/A — Study targets general multimorbidity population without specific disease focus or explicit palliative care integration
|
N/A
early palliative care → early palliative care → N/A
shaky reasoning✓ Unanimous
Initial: early palliative care
Requery: early palliative care — The study targets early integration of care coordination and symptom management for older adults with multimorbidity, focusing on improved management and quality of life, and is disease-agnostic.
Thinking: N/A — Population is a general group of older adults with multimorbidity, not focused on any single non-cancer disease category.
|
N/A
N/A
shaky reasoning✓ Unanimous
Initial: N/A
|
OK |
| setting_patient | mixed | mixed | mixed | OK |
| setting_place | hospital | hospital | hospital | OK |
| feasibility | feasibility RCT | feasibility RCT | feasibility RCT | OK |
| intervention_pharmacologic | no | no | no | OK |
| intervention_chemo_immuno_radio | no | no | no | OK |
| intervention_complementary | no | no | no | OK |
| intervention_device | no | no | no | OK |
| intervention_psychological | no | no | no | OK |
| intervention_complex | yes | yes | yes | OK |
| intervention_acp |
yes
yes → yes → no
shaky reasoning✗ No consensus
Initial: yes
Requery: yes — The enhanced usual care group receives guidance on advance care planning as part of their resource toolkit with educational materials, and the COORDINATE program includes goals of care discussions which are a core component of advance care planning.
Thinking: no — The COORDINATE intervention focuses on care coordination and symptom management without specific ACP components like advance directives or structured end-of-life planning discussions.
|
yes
yes → yes → yes
shaky reasoning✗ No consensus
Initial: yes
Requery: yes — The COORDINATE Program includes structured goals-of-care discussions, which is a major focus of advance care planning.
Thinking: yes — The COORDINATE intervention explicitly includes a structured Goals-of-Care discussion, making advance care planning a core component of the program.
|
no
no → no
shaky reasoning✗ No consensus
Initial: no
Requery: no — The COORDINATE intervention focuses on general care coordination and symptom management, and while the enhanced usual care toolkit mentions advance care planning, it is only incidental educational content and not a structured component of the primary intervention.
|
|
| intervention_music | no | no | no | OK |
| intervention_screening |
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The COORDINATE Program is a comprehensive care coordination and symptom management intervention, not a screening tool to identify palliative care needs.
|
no
yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: no — The trial evaluates a care coordination and symptom management program, not a screening tool.
|
no
no
shaky reasoning✓ Unanimous
Initial: no
|
OK |
| intervention_palliative | yes | yes | yes | OK |
| intervention_education | yes | yes | yes | OK |
| intervention_digital |
no
no → yes → no
shaky reasoning✓ Unanimous
Initial: no
Requery: yes — The intervention specifically includes video visits as a core delivery mechanism for the discharge planning visit and follow-up calls, making digital technology central to the COORDINATE program delivery.
Thinking: no — The COORDINATE Program is a nurse-led intervention where phone/video calls are merely communication methods, not the core intervention mechanism.
|
no
yes → yes → no
shaky reasoning✓ Unanimous
Initial: yes
Requery: yes — The COORDINATE Program's intervention includes video calls, which are a core part of the intervention delivery mechanism.
Thinking: no — The core intervention is nurse-led care coordination with optional phone or video calls, so digital technology is not the primary or essential delivery mechanism.
|
no
no → no
shaky reasoning✓ Unanimous
Initial: no
Requery: no — The COORDINATE Program is a nurse-led intervention primarily delivered through in-person or phone-based contact, where technology is only a peripheral communication option (video) and not the core delivery mechanism.
|
OK |
| intervention_other | no | no | no | OK |
| outcome_symptom |
yes
no → yes
shaky reasoning✓ Unanimous
Initial: no
Requery: yes — The EuroQoL includes assessment of pain/discomfort and anxiety/depression as specific symptom domains, and the intervention includes structured symptom monitoring using a symptom checklist.
|
yes
yes → yes
shaky reasoning✓ Unanimous
Initial: yes
Requery: yes — The trial includes symptom monitoring and tracking as a component of the COORDINATE intervention, which assesses symptoms directly.
|
yes
no
shaky reasoning✓ Unanimous
Initial: no
|
OK |
| outcome_qol | yes | yes | yes | OK |
| outcome_dignity | no | no | no | OK |
| outcome_cost | yes | yes | yes | OK |
| outcome_other |
no
no → no → yes
shaky reasoning✗ No consensus
Initial: no
Requery: no — All outcomes focus on quality of life (EuroQoL measures) and healthcare utilization (emergency department visits, critical care admissions, rehospitalizations), which fall under the symptom/QoL/dignity/cost categories.
Thinking: yes — Secondary outcomes include healthcare utilization measures (ED visits, critical care admissions, rehospitalizations) which are not covered by symptom/QoL/dignity/cost categories.
|
yes
yes → yes → no
shaky reasoning✗ No consensus
Initial: yes
Requery: yes — The trial includes outcomes such as reducing emergency visits, intensive care admissions, and rehospitalizations, which do not fall under symptom/QoL/dignity/cost categories.
Thinking: no — All measured outcomes pertain to quality of life or healthcare utilization/cost, with no additional categories such as caregiver effects, communication quality, or goal‐concordant care.
|
no
no → yes
shaky reasoning✗ No consensus
Initial: no
Requery: yes — The secondary outcomes include healthcare utilization metrics (emergency department visits, critical care admissions, and rehospitalizations), which are cost-related outcomes that fall outside of symptom/QoL/dignity categories.
|
|
| pharmacologic_sub | N/A | N/A | N/A | OK |