NCT07216404

Exploring the Safety, Acceptability, and Efficacy of Psilocybin Among Non-Small Cell Lung Cancer Patients With Major Depressive Disorder: A Proof-of-Concept Trial (DREAM LUNG STUDY)

Extracted Fields (from Registry)
Protocol IDNCT07216404
Registration Date2025-10-14
Statusrecruiting
SponsorAlan Davis
CountryUnited States
Industrynot industry
Blindingunblinded
Center Typesingel-center RCT
Scopenational RCT
First Patient In2026-04-15
Last Patient Out2027-10-31
Publicationn
Gender %ALL
Mean Age18 Years -
LLM Classifications (Side-by-Side)
Field CLAUDE
claude-sonnet-4-20250514
6681ms / 12865 tok 		OPENAI
gpt-4o
6397ms / 11098 tok 		GLM
glm-5.1
8621ms / 11277 tok 		Review
rct_type N/A N/A N/A OK
cancer_status Cancer Cancer Cancer OK
non_cancer_spec N/A N/A N/A OK
setting_patient outpatient outpatient outpatient OK
setting_place other other other OK
feasibility feasibility RCT feasibility RCT feasibility RCT OK
intervention_pharmacologic yes yes yes OK
intervention_chemo_immuno_radio no no no OK
intervention_complementary no no no OK
intervention_device no no no OK
intervention_psychological yes yes yes OK
intervention_complex yes yes yes OK
intervention_acp no no no OK
intervention_music no no no OK
intervention_screening no no no OK
intervention_palliative no yes → no
shaky reasoning
✓ Unanimous Initial: yes Requery: no — This study tests psilocybin as a pharmacologic intervention for depression in lung cancer patients, not palliative care consultation or service delivery as the intervention.
 no no → no
shaky reasoning
✓ Unanimous Initial: no Requery: no — The trial tests the safety and efficacy of psilocybin-assisted therapy for depression in lung cancer patients, not palliative care as an intervention.
 no yes → no
shaky reasoning
✓ Unanimous Initial: yes Requery: no — The intervention is a pharmacologic drug trial (psilocybin) paired with psychotherapy to treat depression in cancer patients, which is a specific therapy tested within a cancer care setting rather than testing palliative care itself as the intervention.
 OK
intervention_education no no no OK
intervention_digital no no no OK
intervention_other no no no OK
outcome_symptom yes yes yes OK
outcome_qol yes yes yes OK
outcome_dignity yes yes yes OK
outcome_cost no no no OK
outcome_other yes yes yes OK
pharmacologic_sub controlled substances controlled substances controlled substances OK
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